- Bethel is a city located in the western part of the U.S. state of Alaska. It is situated on the Kuskokwim River and is the largest community in the Yukon-Kuskokwim Delta region. Bethel serves as a regional hub for many surrounding villages and is known for its diverse population, with a large number of Alaska Native peoples. The city is known for its rich culture, tradition, and its vibrant arts scene.